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Pre-complexed GHK-Cu delivers a defined copper payload directly to tissues and activates copper-dependent enzymatic pathways including lysyl oxidase (collagen crosslinking) and superoxide dismutase immediately upon cellular uptake

This was an important part of the study design, allowing researchers to track a placebo group throughout the trial

administration 58, 59, 60, 61 of Ang II produced dose-dependent decreases in total renal blood flow (RBF) and renal cortical blood flow (CBF), and increases in renal vascular resistance and renal cortical vascular resistance, which were blocked by AT 1 receptor antagonists

Some also saw better blood pressure, cholesterol, and overall health